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Issues of atopic dermatitis in context of nutrition
HAVLOVÁ, Ivona
The topic of my bachelor's thesis is "Issues of atopic dermatitis in context of nutrition." Atopic dermatitis is a type of skin inflammation in moist areas (back of the knee, inner elbow, groin). Skin health is affected by factors including the weather, textile and diet. Data were gathered using a qualitative research and snowball sampling. A survey was conducted among nine respondents, each providing information on the food they ate for a week. The goal was to map atopic dermatitis in the context of nutrition. The practical part of the thesis focused on what foods seem to be the most problematic for respondents. The survey showed these include citrus fruit, sweets, highly processed foods and especially alcohol. Respondents said that wine was the most problematic among alcoholic beverages. A few respondents mentioned nuts, soya and dairy. Seasons also have an impact on the atopic dermatitis incidence, with winter posing the biggest problem and summer following. A link between atopic dermatitis and the weather has not been properly studied and cannot be confirmed. The food analysis was recorded in the Nutriservis app. Data were entered into an Excel table that includes energy and macronutrient values of individual meals. The analysis shows that most respondents eat bread/rolls with ham or cheese, or cereal for breakfast. Snacks are similar but smaller than breakfasts. Lunches and dinners are often home-made meals consisting of good polysaccharides (rice, pasta, potatoes), meat (mostly chicken) and vegetables. The analysis reveals often unbalanced energy intake over the week, mostly because of alcohol consumption. Most respondents eat enough fruit and vegetables.
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Pupils' and parents' attitudes towards allergy and food intolerance
MAŠKOVÁ, Pavla
The aim of the work is both to process a search based on the available literature, as well as to determine the level of knowledge and attitudes of students and parents in the form of a questionnaire, the attitudes of teachers and doctors through structured interviews. Furthermore, the aim of the work is to answer the following research questions. 1. Do the level of knowledge and attitudes of pupils and their parents differ? 2. Is school teaching the most important source of information on allergies and food intolerances?
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Information Awarness and Experience of Common People with Food Allergy
Stropková, Romana ; Hošťálková, Monika (advisor) ; Strnadová, Alice (referee)
The bachelor thesis is focused on the problems of the food allergies. The aim was to discover how much the population is informed in this field, if the population has experienced the food allergies, having found the symptoms present on themselves or their friends, family. And finally the awareness of these allergies in a family taking care of an allergic person is studied. In the theoretical part the definitions of the food allergies and similar reactions are explained. It is followed by anatomical and physiological descriptions of digestive and immune systems which are closely related to the food allergy. The causes and symptoms of the food allergies, diagnostics, treatment and prevention are integral to the theoretical part. The importance of probiotics and prebiotics which differs in scientists' opinions and in results of scientific studies is also studied. In the end of this chapter a new antigen and the education of the general public are mentioned. In the empirical part the characteristics of research assignment and methods of the research are described. I chose a questionnaire as a method for data collection. I deal with the results of the questionnaires in this part too. Research shows that the majority of respondents knows what the food allergy is and have an idea of its causes and...
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Comparison of cytokine production by leukocytes from newborns of healthy and allergic mothers
Dusilová, Adéla ; Hrdý, Jiří (advisor) ; Janatková, Ivana (referee)
The increasing incidence of children suffering from allergic diseases could be caused by sensitization of immature immune system during the intrauterine development. Several important scientific papers have demonstrated the ability of cord blood cells to respond by elevated proliferation activity after stimulation by common allergens. Following these findings, present study follows the production of cytokines which play a role in the pro- and anti-allergenic tuning of the immune system. Umbilical cord blood cells were stimulated with polyclonal activators (phytohaemagglutinin) and common allergens (ovalbumin, timothy grass, birch, mite). Subsequently, cytokine production was monitored using selected methods that reflect different stages of cell activation - at the level of mRNA by quantitative real time PCR (qRT-PCR), by flow cytometry detection of the presence of intracellular cytokines in different cell subpopulations and by ELISA measurement of cytokines in CBMC culture supernatants. The results obtained point to a very weak ability of these common allergens (timothy grass, birch, mite, ovalbumin) to stimulate CBMC to produce cytokines observed by all of these methodological procedures. Although we did not observe significant differences in CBMC cytokine production (IL-2, IL-4, IL-10, IL-12,...
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Immunologic Characteristics of Cord Blood in Children with Increased Risk of Allergy Development Preventive Use of Probiotics
Hrdý, Jiří ; Prokešová, Ludmila (advisor) ; Tlaskalová - Hogenová, Helena (referee) ; Ulčová-Gallová, Zdeňka (referee)
Allergy is one of the most common diseases. Identification of early prognostic markers pointing to an increased risk of allergy development is therefore of increasing importance. Cord blood represents an easily attainable clinical material for searching for prognostic markers signalizing future allergy development. Proportions of Th1 cytokines, Th2 cytokines and regulatory cytokines were tested in cord blood of children of allergic mothers (children in relatively high risk of allergy development) in comparison with cord blood of children of healthy mothers (low risk children). Also the activities of lymphocytes, dendritic cells (DC) and regulatory cells (Tregs) were compared in children of healthy and allergic mothers. The generally increased activity of both in vitro stimulated and non-stimulated mononuclear cord blood leukocytes was proved in children of allergic mothers in comparison with low risk children. The increased activity of DC of high risk children was detectable only after polyclonal stimulation. Significantly less pronounced functional properties of cord blood Tregs were found in children of allergic mothers when compared with children of healthy mothers. The increased reactivity of lymphocytes and DC together with the decreased activity of Tregs can support an easier...
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Pollens of Selected Alergenic Plants and their Didactic Use in Teaching Biology at High Schools
Pýchová, Adéla ; Skýbová, Jana (advisor) ; Říhová, Dagmar (referee)
In my thesis I deal with the pollen of allergenic plants, the origin and proces of allergy to plant pollen and the inclusion of these topics in the teaching of plant biology in high schools. In the theoretical part I focus on topic of pollen allergy. First, I generally describe allergy and its origin, causes of allergic diseases, environmental factors and the development of allergic disease. I also briefly address the naming and registration of allergens and I also mention the so-called cross-allergy. Great emphasis is placed on pollen allergy, which is devoted to a larger unit, divided into individual subchapters dealing with the physiological function of the nose, followed by an allergic reaction of type I, an allergic reaction that occurs on the nasal mucosa. Furthermore, subchapters mentioning the classification of allergic rhinitis, diagnosis and pharmacotherapy, including additions to the drug groups used in the treatment of pollen allergy. Another larger unit is devoted to the structure of the plant's blossom as a source of allergen, which includes the anatomy of the blossom parts and a description of the pollen grain. The anatomical description of the blossom is followed by a practical part, first created by a tabular overview with selected allergenic plants. Each plant causing the allergy...
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Immunoregulatory characteristics of immune cells of children of allergic and non-allergic mothers and the possibility of their modulation with probiotic E. coli strain O83:K24:H31
Černý, Viktor ; Hrdý, Jiří (advisor) ; Tlaskalová - Hogenová, Helena (referee) ; Černá, Marie (referee)
Due to high incidence, medical and socioeconomic burden and impact on individual quality of life and productivity, allergic disorders are a crucial issue for 21st century immunology. Much still remains to be elucidated, particularly regarding the very early processes in allergy development. In order to introduce timely, effective preventive measures, novel, more reliable predictive factors of allergy risk also need to be established. Dysregulation of proper balance between the branches of immune response, particularly unwarranted dominance of Th2, is the underlying cause of allergy. After birth, new immune balance needs to be established to prepare the neonate for adequate reactivity towards newly encountered environmental stimuli. Regulatory T cells (Treg) play a central role in finely setting this balance and inducing tolerance towards harmless environmental antigens, including allergens. Interactions with external factors, most importantly microbiota, modulate this process during the early postnatal "window of opportunity." Analysis of cord blood Treg of children of allergic mothers uncovered decreased presence of function-associated surface markers and lower production of IL-10. Furthermore, decreased proportion of Helios- induced Treg was observed in children with higher risk of allergy....
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Pollens of Selected Alergenic Plants and Their Didactic Use in Teaching Biology at High Schools
Pýchová, Adéla ; Skýbová, Jana (advisor) ; Říhová, Dagmar (referee)
7 Abstract The thesis is focused on the pollen of selected allergenic plants. Thesis is structured into two parts., pollination and fertilization , development of the pollen grain , its structure and chemical composition. The end of the theoretical part, dedicated to allergies, is divided into subsections dealing with First, teoretical part describes the flower and its morphology, discusses the pollen grain, stamen anatomical structure immunity and allergies, naming and registration of allergens and cross- pollen allergy . The practical part contains an analysis of curriculum for students of secondary schools. An integral part of the work is a survey of teachers in secondary schools, in which method of questioning was used. The aim of this questioning was to determine the presence of solved issue in terms of representation of pollen and pollen allergens in textbooks for secondary schools , as well as the inclusion of this issue in the official curriculum, under the National Programme for the Development of Education in the Czech Republic. Based on the results of a questionnaire survey of secondary school teachers, teaching materials have been developed in the form of two worksheets for teaching botany and guidance on laboratory exercises in plant biology.
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